Tissue Repair Technologies

Tissue Repair Technologies Market Outlook

The global Tissue Repair Technologies market was valued at approximately USD 30 billion in 2023 and is projected to grow at a compound annual growth rate (CAGR) of around 8% during the forecast period from 2025 to 2035. This robust growth is attributed to the increasing prevalence of chronic diseases, rising awareness regarding advanced wound care treatments, and the growing geriatric population globally. In addition, technological advancements in tissue engineering and regenerative medicine have led to the development of innovative solutions, thereby enhancing the efficiency of tissue repair processes. Furthermore, favorable government initiatives and increased funding for research and development in tissue repair technologies are expected to bolster market expansion. This growth trajectory is further supported by the rising demand for minimally invasive surgical procedures, which facilitate quicker recovery and reduced hospital stays.

Growth Factor of the Market

The growth of the Tissue Repair Technologies market is significantly influenced by the increasing incidence of musculoskeletal disorders and injuries, which often require advanced treatment options for effective recovery. As the global population ages, the demand for tissue repair solutions is expected to rise due to the prevalent age-related conditions that affect joint and tissue health. Additionally, advancements in biomaterials and biocompatible scaffolds have revolutionized the market by providing innovative products that enhance healing processes. Research and development initiatives focused on developing new therapeutic methods and technologies are also driving market growth, as they enable more effective treatment options tailored to patient needs. Moreover, the growing trend of personalized medicine is influencing the market, as providers seek customized solutions that can lead to better patient outcomes.

Key Highlights of the Market

• Increasing prevalence of chronic wounds and surgical site infections.
• Technological advancements in tissue engineering and regenerative medicine.
• Rapid growth in the geriatric population leading to higher demand for tissue repair products.
• Rising healthcare expenditure and investment in R&D activities.
• Focus on minimally invasive surgical techniques that accelerate recovery times.

By Product Type

Scaffold-based:

Scaffold-based technologies play a crucial role in tissue repair by providing a temporary structure that supports cell attachment and growth. These scaffolds serve as a framework for tissue regeneration, enabling the infiltration of cells and promoting vascularization. Composed from various materials, including natural and synthetic polymers, scaffold-based products can be designed to match the mechanical and biological properties of the native tissue. The increasing adoption of scaffold-based technologies in clinical applications, such as orthopedic and dental procedures, is driving the growth of this segment. Additionally, innovations like 3D printing have enhanced the customization of scaffolds, allowing for tailored solutions that fit the unique anatomy of each patient.

Cell-based:

Cell-based tissue repair technologies involve the use of living cells to restore, replace, or regenerate damaged tissues. This type of technology has gained traction due to its potential to provide long-term solutions for conditions that traditional therapies cannot fully address. For instance, stem cells are increasingly utilized in regenerative medicine for their ability to differentiate into various cell types, making them ideal for treating injuries and degenerative diseases. The growing body of research supporting the efficacy of cell-based therapies is propelling this segment forward, as healthcare providers seek innovative approaches to enhance healing processes. Furthermore, the rise in clinical trials examining the use of cell-based therapies is indicative of their promising future in the tissue repair market.

Growth Factor-based:

Growth factor-based technologies leverage proteins that are naturally occurring in the body to stimulate cellular growth, proliferation, and differentiation. Produced either through recombinant DNA technology or extracted from biological sources, these growth factors can significantly enhance tissue repair by modulating the healing process. The increasing understanding of the role of growth factors in tissue regeneration is driving demand in this segment, particularly in applications like orthopedic surgery and wound care management. Additionally, the ability to deliver these growth factors through advanced delivery systems for targeted therapy further amplifies their effectiveness, making them a focal point for ongoing research and product development in the market.

Biomaterials:

Biomaterials are substances engineered to interact with biological systems for medical purposes, and they are crucial in tissue repair technologies. These materials can be natural or synthetic, designed to mimic the properties of native tissue and promote healing. The versatility of biomaterials enables their application across various medical fields, such as orthopedics, cardiology, and dermatology. As healthcare providers increasingly recognize the importance of biomaterials in enhancing recovery rates and reducing complications, the demand for these products continues to grow. Innovations in biomaterials, such as bioactive materials and nanotechnology, are expected to further enhance their applications in tissue repair, driving market expansion.

Others:

This category encompasses a range of innovative technologies and products that do not fall under the primary classifications of scaffold-based, cell-based, growth factor-based, or biomaterials. Emerging solutions, including gene therapy and combination therapies that integrate multiple techniques, are gaining attention in the tissue repair landscape. With the continuous advancements in the field of biotechnology, this segment is poised for substantial growth as new methodologies arise to address complex tissue repair challenges. The increasing focus on personalized medicine and tailored treatment modalities is also expected to propel the development of novel products within this category, further enriching the overall tissue repair technologies market.

By Application

Orthopedic:

The orthopedic application segment represents one of the largest markets for tissue repair technologies, primarily due to the increasing prevalence of musculoskeletal disorders and sports-related injuries. Treatments such as cartilage repair and bone regeneration utilize advanced technologies, including scaffolds and growth factors, to enhance healing outcomes. The rise in surgical interventions, coupled with an aging population that is prone to orthopedic issues, is driving demand in this segment. Additionally, the growing trend of minimally invasive surgeries is leading to innovations that improve recovery times and patient satisfaction, thereby bolstering market growth.

Dermatology:

In dermatology, tissue repair technologies are increasingly employed for wound healing and skin regeneration applications. The rising incidence of chronic wounds, such as diabetic ulcers and pressure sores, necessitates effective treatment solutions that can promote rapid healing. Advanced technologies, including bioactive dressings and skin substitutes, are designed to mimic the natural skin environment, facilitating tissue regeneration. Additionally, the growing awareness regarding advanced cosmetic procedures and anti-aging treatments is contributing to the expansion of this segment, as consumers seek innovative solutions that improve aesthetic outcomes.

Cardiovascular:

The cardiovascular application segment in the tissue repair technologies market focuses on addressing heart-related conditions, such as myocardial infarction and heart valve repair. Technologies such as bioengineered vascular grafts and cardiac patches are being developed to enhance repair processes and improve patient outcomes. The increasing prevalence of cardiovascular diseases, coupled with the rising demand for surgical interventions, is driving growth in this segment. Moreover, ongoing research aimed at developing new regenerative therapies and biomaterials for cardiovascular applications is expected to further elevate the importance of this segment within the tissue repair market.

Neurology:

In the neurology application segment, tissue repair technologies are gaining traction for their potential to treat conditions such as spinal cord injuries and neurodegenerative diseases. The development of innovative scaffolds and cell-based therapies is paving the way for enhanced recovery in patients suffering from neurological disorders. As awareness regarding the importance of brain health increases, the demand for effective treatment options within this segment is on the rise. Furthermore, ongoing advancements in neuroscience and neuroengineering are likely to contribute to the growth of this segment, as researchers explore new methodologies to repair and regenerate damaged neural tissues.

Others:

This category includes a variety of applications outside the primary segments, such as dental applications and reconstructive surgery. Tissue repair technologies are increasingly being incorporated into dental procedures, including bone grafting and periodontal therapies, to facilitate healing and regeneration. Additionally, advancements in regenerative medicine are enhancing outcomes in reconstructive surgeries, driving demand for innovative solutions. The diverse range of applications within this category signifies the versatility of tissue repair technologies and their potential to meet various medical needs.

By Distribution Channel

Hospitals:

Hospitals remain one of the primary distribution channels for tissue repair technologies, as they serve as the main treatment facilities for patients requiring surgical interventions. Given their comprehensive medical services, hospitals are well-equipped to provide advanced therapies and products that support tissue repair. The increasing number of surgical procedures conducted within hospital settings, coupled with the growing demand for specialized care, is driving the growth of this channel. Additionally, hospitals are often involved in clinical trials and research initiatives, further enhancing their role as key players in the distribution of tissue repair technologies.

Ambulatory Surgical Centers:

Ambulatory surgical centers (ASCs) have gained popularity as an alternative distribution channel for tissue repair technologies, particularly for outpatient procedures. These centers offer several advantages, including reduced wait times and lower costs, making them increasingly attractive to patients. The rise in minimally invasive surgical procedures performed in ASCs is expected to drive the demand for tissue repair products in this setting. Furthermore, ASCs often focus on specific specialties, allowing them to provide tailored solutions that cater to the unique needs of patients requiring tissue repair interventions.

Specialty Clinics:

Specialty clinics are becoming a significant distribution channel for tissue repair technologies, as they focus on specific medical fields such as orthopedics, dermatology, and neurology. These clinics often adopt advanced technologies and innovative products tailored to their specialized practices, enhancing the effectiveness of treatments offered. The increasing prevalence of specialized care and the growing focus on personalized medicine are contributing to the expansion of this channel. Patients seeking targeted therapies are turning to specialty clinics for the advanced solutions they offer, further driving demand for tissue repair technologies.

Online Sales:

The online sales channel for tissue repair technologies is rapidly gaining traction, especially as the healthcare industry embraces digital transformation. The convenience of e-commerce platforms allows patients and healthcare providers to access a wide range of products from the comfort of their homes. Online sales facilitate increased awareness of available tissue repair solutions and provide access to information on innovative products. Moreover, the growing trend of telemedicine and remote consultations is further promoting online sales, as healthcare providers increasingly recommend products through digital channels, contributing to the overall growth of this distribution segment.

By Ingredient Type

Collagen:

Collagen is a primary ingredient in tissue repair technologies due to its biocompatibility and natural abundance in the body. As a key structural protein, collagen provides strength and support to tissues, making it essential for wound healing and tissue regeneration applications. The increasing use of collagen-based products in various medical fields, including orthopedic and dermatological applications, is driving demand in this segment. Innovations in collagen formulations, such as cross-linking and modifications to enhance stability, are further propelling the growth of this ingredient type in the tissue repair market.

Hyaluronic Acid:

Hyaluronic acid, known for its hydrating properties, is widely used in tissue repair technologies due to its ability to promote healing and tissue regeneration. This naturally occurring substance plays a critical role in maintaining skin elasticity and hydration, making it a valuable ingredient in wound care and dermatology applications. The increasing focus on advanced wound care products and the demand for aesthetic treatments are driving the growth of hyaluronic acid in the market. Furthermore, ongoing research into new formulations and delivery methods is expected to enhance the effectiveness of hyaluronic acid-based products, contributing to their expanded use in tissue repair technologies.

Platelet-rich Plasma:

Platelet-rich plasma (PRP) is gaining prominence in tissue repair technologies due to its regenerative properties. Derived from the patient’s blood, PRP contains a concentration of growth factors that can significantly enhance healing processes. This ingredient is increasingly utilized in orthopedic, dermatological, and aesthetic applications, where it promotes tissue repair and rejuvenation. The growing acceptance of PRP therapy in various medical fields is driving demand for this ingredient, as patients seek innovative solutions for faster recovery and improved outcomes. Furthermore, advancements in PRP preparation techniques are expected to further enhance its clinical applications, bolstering its presence in the tissue repair market.

Stem Cells:

Stem cells represent a groundbreaking ingredient in tissue repair technologies, providing the potential for regenerative therapies that can restore damaged tissues. Their unique ability to differentiate into various cell types and regenerate damaged tissues positions them as a key component in advanced treatments for chronic wounds and degenerative diseases. The increasing investment in stem cell research and clinical applications is propelling the growth of this ingredient type in the market. As stem cell therapies gain acceptance and evidence supporting their efficacy continues to mount, their application in tissue repair technologies is expected to expand significantly.

Others:

This category includes a variety of other ingredients utilized in tissue repair technologies, such as growth factors, biomolecules, and synthetic polymers. The diverse range of ingredients allows for the development of innovative and effective solutions tailored to specific medical needs. The ongoing research into new materials and formulations is driving the growth of this segment, as companies seek to enhance the performance and efficacy of tissue repair products. As the demand for customized solutions continues to rise, the inclusion of various ingredients will play a crucial role in shaping the future of the tissue repair technologies market.

By Region

The North American region currently dominates the Tissue Repair Technologies market, accounting for approximately 45% of the global market share in 2023. This can be attributed to the high prevalence of chronic diseases, advanced healthcare infrastructure, and significant investments in research and development initiatives. The presence of key players in the region and their focus on technological innovations further augment the market growth in North America. The CAGR for the North American market is projected to remain robust, driven by the increasing adoption of minimally invasive procedures and the rising demand for advanced wound care products.

Europe holds the second-largest share of the Tissue Repair Technologies market, representing about 30% of the global market in 2023. The growth in this region is fueled by an aging population, increasing healthcare expenditure, and a rising focus on advanced regenerative medicine techniques. The European market is expected to witness significant growth over the forecast period, driven by innovations in tissue engineering and the growing demand for effective treatment options for orthopedic and dermatological applications. Emerging markets in Asia Pacific and Latin America are also contributing to the overall market expansion as they experience rising healthcare investment and increased awareness of advanced tissue repair technologies.

Opportunities

The Tissue Repair Technologies market is poised for substantial opportunities driven by technological advancements and a growing emphasis on personalized medicine. The rise of innovative solutions such as 3D bioprinting and gene editing technologies presents avenues for creating highly customized tissue repair products that cater to individual patient needs. Such innovations are expected to significantly improve the efficacy and outcomes of tissue repair treatments, making them increasingly attractive to both healthcare professionals and patients. Additionally, the increasing investment in research and development by both public and private sectors is likely to accelerate the pace of innovation, resulting in more effective therapies and diversified product offerings. As awareness of these advanced technologies grows among healthcare providers, adoption rates are expected to rise, further driving market growth.

Furthermore, the increasing prevalence of chronic wounds and surgical site infections presents a pressing need for effective tissue repair solutions. As healthcare systems worldwide grapple with the burden of these conditions, the demand for innovative technologies that facilitate faster healing and improved patient outcomes is expected to surge. Additionally, the expansion of healthcare access in emerging markets, coupled with rising disposable incomes, creates further opportunities for the tissue repair technologies market. Organizations that focus on developing cost-effective products tailored to meet the needs of these growing populations will likely gain a competitive advantage, capitalizing on the expanding market potential. Overall, the convergence of technological advancements and increasing healthcare demands creates a fertile environment for growth in the tissue repair technologies market.

Threats

Despite the promising growth prospects of the Tissue Repair Technologies market, several threats could hinder market expansion. One significant challenge is the stringent regulatory requirements imposed by healthcare authorities, which can delay the approval of new products and technologies. The complex nature of tissue repair products often necessitates extensive clinical trials and evaluations, leading to longer timelines for market entry. Additionally, the high costs associated with research and development can deter smaller companies from entering the market, limiting the diversity of available solutions. Furthermore, intense competition among established players can lead to price wars, ultimately impacting profit margins and hindering innovation.

Another potential threat arises from the rapid pace of technological advancements, which can make existing solutions obsolete. Companies must continuously invest in innovation to stay competitive and address the evolving needs of healthcare providers and patients. Failure to keep up with these advancements can result in a loss of market share and relevance. Additionally, economic fluctuations and changes in healthcare funding can impact the overall demand for tissue repair technologies, particularly in regions heavily reliant on government support. As healthcare systems face budget constraints, prioritizing investments in advanced technologies may become challenging, thereby impacting market growth. Companies must remain vigilant and adaptable to navigate these threats and sustain their competitive positions in the tissue repair technologies market.

Competitor Outlook

• Integra LifeSciences Corporation
• Medtronic plc
• Organogenesis Holdings Inc.
• Allergan plc (AbbVie Inc.)
• Smith & Nephew plc
• Stryker Corporation
• Collagen Matrix, Inc.
• RTI Surgical Holdings, Inc.
• MiMedx Group, Inc.
• Vericel Corporation
• Medline Industries, Inc.
• Hollister Incorporated
• 3M Company
• Tissue Regenix Group plc
• Polyganics B.V.

The competitive landscape of the Tissue Repair Technologies market is characterized by the presence of both established players and emerging companies that are striving to gain a foothold in this rapidly growing sector. Major companies in the market are focusing on strategic collaborations, mergers and acquisitions, and product innovation to enhance their market presence and expand their product portfolios. The competitive dynamics are further influenced by technological advancements and increasing investment in research and development, as companies seek to develop cutting-edge solutions that cater to the evolving needs of healthcare providers and patients. This competitive environment encourages organizations to invest in their capabilities, resulting in a continuous flow of innovative products entering the market.

Integra LifeSciences Corporation is a prominent player in the tissue repair technologies space, known for its advanced regenerative medicine products and solutions. The company’s portfolio includes a range of collagen-based products, tissue scaffolds, and wound care solutions that cater to various medical applications. With a strong focus on innovation, Integra continues to invest in research and development to enhance its offerings and provide effective solutions for tissue repair and regeneration.

Medtronic plc, another key player in the market, is recognized for its wide range of medical technologies, including tissue repair solutions. The company’s extensive experience and innovative capabilities position it as a leader in the development of products that address complex tissue repair challenges. Medtronic's commitment to advancing healthcare through cutting-edge technologies and solutions underscores its significant role in the tissue repair technologies market, making it a formidable competitor.

• 1 Appendix

  • 1.1 List of Tables
  • 1.2 List of Figures

• 2 Introduction

  • 2.1 Market Definition
  • 2.2 Scope of the Report
  • 2.3 Study Assumptions
  • 2.4 Base Currency & Forecast Periods

• 3 Market Dynamics

  • 3.1 Market Growth Factors
  • 3.2 Economic & Global Events
  • 3.3 Innovation Trends
  • 3.4 Supply Chain Analysis

• 4 Consumer Behavior

  • 4.1 Market Trends
  • 4.2 Pricing Analysis
  • 4.3 Buyer Insights

• 5 Key Player Profiles

  • 5.1 3M Company
    • 5.1.1 Business Overview
    • 5.1.2 Products & Services
    • 5.1.3 Financials
    • 5.1.4 Recent Developments
    • 5.1.5 SWOT Analysis
  • 5.2 Medtronic plc
    • 5.2.1 Business Overview
    • 5.2.2 Products & Services
    • 5.2.3 Financials
    • 5.2.4 Recent Developments
    • 5.2.5 SWOT Analysis
  • 5.3 Polyganics B.V.
    • 5.3.1 Business Overview
    • 5.3.2 Products & Services
    • 5.3.3 Financials
    • 5.3.4 Recent Developments
    • 5.3.5 SWOT Analysis
  • 5.4 MiMedx Group, Inc.
    • 5.4.1 Business Overview
    • 5.4.2 Products & Services
    • 5.4.3 Financials
    • 5.4.4 Recent Developments
    • 5.4.5 SWOT Analysis
  • 5.5 Smith & Nephew plc
    • 5.5.1 Business Overview
    • 5.5.2 Products & Services
    • 5.5.3 Financials
    • 5.5.4 Recent Developments
    • 5.5.5 SWOT Analysis
  • 5.6 Stryker Corporation
    • 5.6.1 Business Overview
    • 5.6.2 Products & Services
    • 5.6.3 Financials
    • 5.6.4 Recent Developments
    • 5.6.5 SWOT Analysis
  • 5.7 Vericel Corporation
    • 5.7.1 Business Overview
    • 5.7.2 Products & Services
    • 5.7.3 Financials
    • 5.7.4 Recent Developments
    • 5.7.5 SWOT Analysis
  • 5.8 Collagen Matrix, Inc.
    • 5.8.1 Business Overview
    • 5.8.2 Products & Services
    • 5.8.3 Financials
    • 5.8.4 Recent Developments
    • 5.8.5 SWOT Analysis
  • 5.9 Hollister Incorporated
    • 5.9.1 Business Overview
    • 5.9.2 Products & Services
    • 5.9.3 Financials
    • 5.9.4 Recent Developments
    • 5.9.5 SWOT Analysis
  • 5.10 Medline Industries, Inc.
    • 5.10.1 Business Overview
    • 5.10.2 Products & Services
    • 5.10.3 Financials
    • 5.10.4 Recent Developments
    • 5.10.5 SWOT Analysis
  • 5.11 Tissue Regenix Group plc
    • 5.11.1 Business Overview
    • 5.11.2 Products & Services
    • 5.11.3 Financials
    • 5.11.4 Recent Developments
    • 5.11.5 SWOT Analysis
  • 5.12 Allergan plc (AbbVie Inc.)
    • 5.12.1 Business Overview
    • 5.12.2 Products & Services
    • 5.12.3 Financials
    • 5.12.4 Recent Developments
    • 5.12.5 SWOT Analysis
  • 5.13 Organogenesis Holdings Inc.
    • 5.13.1 Business Overview
    • 5.13.2 Products & Services
    • 5.13.3 Financials
    • 5.13.4 Recent Developments
    • 5.13.5 SWOT Analysis
  • 5.14 RTI Surgical Holdings, Inc.
    • 5.14.1 Business Overview
    • 5.14.2 Products & Services
    • 5.14.3 Financials
    • 5.14.4 Recent Developments
    • 5.14.5 SWOT Analysis
  • 5.15 Integra LifeSciences Corporation
    • 5.15.1 Business Overview
    • 5.15.2 Products & Services
    • 5.15.3 Financials
    • 5.15.4 Recent Developments
    • 5.15.5 SWOT Analysis

• 6 Market Segmentation

  • 6.1 Tissue Repair Technologies Market, By Application
    • 6.1.1 Orthopedic
    • 6.1.2 Dermatology
    • 6.1.3 Cardiovascular
    • 6.1.4 Neurology
    • 6.1.5 Others
  • 6.2 Tissue Repair Technologies Market, By Product Type
    • 6.2.1 Scaffold-based
    • 6.2.2 Cell-based
    • 6.2.3 Growth Factor-based
    • 6.2.4 Biomaterials
    • 6.2.5 Others
  • 6.3 Tissue Repair Technologies Market, By Ingredient Type
    • 6.3.1 Collagen
    • 6.3.2 Hyaluronic Acid
    • 6.3.3 Platelet-rich Plasma
    • 6.3.4 Stem Cells
    • 6.3.5 Others
  • 6.4 Tissue Repair Technologies Market, By Distribution Channel
    • 6.4.1 Hospitals
    • 6.4.2 Ambulatory Surgical Centers
    • 6.4.3 Specialty Clinics
    • 6.4.4 Online Sales

• 7 Competitive Analysis

  • 7.1 Key Player Comparison
  • 7.2 Market Share Analysis
  • 7.3 Investment Trends
  • 7.4 SWOT Analysis

• 8 Research Methodology

  • 8.1 Analysis Design
  • 8.2 Research Phases
  • 8.3 Study Timeline

• 9 Future Market Outlook

  • 9.1 Growth Forecast
  • 9.2 Market Evolution

• 10 Geographical Overview

  • 10.1 Europe - Market Analysis
    • 10.1.1 By Country
      • 10.1.1.1 UK
      • 10.1.1.2 France
      • 10.1.1.3 Germany
      • 10.1.1.4 Spain
      • 10.1.1.5 Italy
  • 10.2 Asia Pacific - Market Analysis
    • 10.2.1 By Country
      • 10.2.1.1 India
      • 10.2.1.2 China
      • 10.2.1.3 Japan
      • 10.2.1.4 South Korea
  • 10.3 Latin America - Market Analysis
    • 10.3.1 By Country
      • 10.3.1.1 Brazil
      • 10.3.1.2 Argentina
      • 10.3.1.3 Mexico
  • 10.4 North America - Market Analysis
    • 10.4.1 By Country
      • 10.4.1.1 USA
      • 10.4.1.2 Canada
  • 10.5 Middle East & Africa - Market Analysis
    • 10.5.1 By Country
      • 10.5.1.1 Middle East
      • 10.5.1.2 Africa
  • 10.6 Tissue Repair Technologies Market by Region

• 11 Global Economic Factors

  • 11.1 Inflation Impact
  • 11.2 Trade Policies

• 12 Technology & Innovation

  • 12.1 Emerging Technologies
  • 12.2 AI & Digital Trends
  • 12.3 Patent Research

• 13 Investment & Market Growth

  • 13.1 Funding Trends
  • 13.2 Future Market Projections

• 14 Market Overview & Key Insights

  • 14.1 Executive Summary
  • 14.2 Key Trends
  • 14.3 Market Challenges
  • 14.4 Regulatory Landscape

Segments Analyzed in the Report

The global Tissue Repair Technologies market is categorized based on

By Product Type

• Scaffold-based
• Cell-based
• Growth Factor-based
• Biomaterials
• Others

By Application

• Orthopedic
• Dermatology
• Cardiovascular
• Neurology
• Others

By Distribution Channel

• Hospitals
• Ambulatory Surgical Centers
• Specialty Clinics
• Online Sales

By Ingredient Type

• Collagen
• Hyaluronic Acid
• Platelet-rich Plasma
• Stem Cells
• Others

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

Key Players

• Integra LifeSciences Corporation
• Medtronic plc
• Organogenesis Holdings Inc.
• Allergan plc (AbbVie Inc.)
• Smith & Nephew plc
• Stryker Corporation
• Collagen Matrix, Inc.
• RTI Surgical Holdings, Inc.
• MiMedx Group, Inc.
• Vericel Corporation
• Medline Industries, Inc.
• Hollister Incorporated
• 3M Company
• Tissue Regenix Group plc
• Polyganics B.V.