Collagen Sponge

Collagen Sponge Market Outlook

The global collagen sponge market was valued at approximately USD 1.1 billion in 2023 and is projected to reach about USD 1.78 billion by 2035, growing at a CAGR of around 6.8% during the forecast period. This growth is being propelled by the rising demand for advanced wound care products, the increasing prevalence of chronic wounds, and the growing adoption of collagen-based products in surgical procedures. Furthermore, advancements in regenerative medicine and the increased focus on aesthetic procedures are also contributing to market growth. The surge in healthcare expenditure and the improvement in healthcare infrastructure across both developed and developing regions are enabling wider access and adoption of these products, thus catalyzing the expansion of the market.

Growth Factor of the Market

The collagen sponge market is experiencing a notable growth rate primarily due to the increasing awareness among healthcare professionals regarding the benefits of collagen sponges in various surgical applications. These sponges are widely recognized for their biocompatibility, promoting cellular proliferation and tissue regeneration, which are critical factors in orthopedic and dental surgeries. Additionally, the rise in the geriatric population, coupled with a higher incidence of age-related health issues, is driving the demand for effective wound care solutions. Another significant factor contributing to market growth is the technological advancements in collagen manufacturing processes, improving the quality and efficiency of collagen sponges. Moreover, the rising trend of minimally invasive surgeries further promotes the adoption of collagen-based products, as they offer reduced recovery times and lower complication rates. Lastly, the growing inclination towards aesthetic procedures, where collagen sponges are increasingly utilized, is expected to further bolster market expansion.

Key Highlights of the Market

• The market is projected to grow at a CAGR of 6.8% from 2023 to 2035, indicating robust growth potential.
• North America holds the largest market share owing to advanced healthcare facilities and high expenditure on healthcare.
• The rising prevalence of chronic wounds and surgical procedures is significantly driving market demand.
• Technological advancements in collagen production and applications are enhancing product efficacy and safety.
• The increase in the geriatric population is contributing to a higher demand for collagen sponges in wound care applications.

By Product Type

Gelatin-based Collagen Sponge:

Gelatin-based collagen sponges are increasingly popular within the market due to their superior biocompatibility and biodegradability, making them ideal for various medical applications. These sponges facilitate cell adhesion and proliferation, which are essential for effective wound healing. Their porous structure allows for the absorption of exudates from wounds while simultaneously providing a moist environment conducive to healing. As a result, they are widely utilized in surgical applications and wound management. The gelatin-based sponges are particularly favored in surgeries due to their ability to support tissue regeneration and minimize scarring, further enhancing their market presence.

Native Collagen Sponge:

Native collagen sponges are derived from animal tissues and maintain the natural structure of collagen, which offers superior biological properties. These sponges are primarily used in orthopedic and dental surgeries, where they serve as scaffolds for tissue repair and regeneration. Their ability to promote angiogenesis and integrate seamlessly with host tissues makes them a preferred choice among surgeons. This type of collagen sponge is particularly effective in supporting the healing process in complex surgical procedures, thus driving its demand in the market. Furthermore, as the focus on minimally invasive techniques increases, the utility of native collagen sponges is expected to rise significantly.

Composite Collagen Sponge:

Composite collagen sponges are engineered products designed to enhance functionality by combining collagen with other bioactive materials. This innovative approach enhances their mechanical properties and promotes faster healing. These sponges are gaining traction in the market due to their versatility and effectiveness in various applications, including wound care and orthopedic surgeries. By leveraging the benefits of multiple constituents, composite sponges often exhibit improved performance characteristics such as enhanced moisture retention and controlled release of therapeutic agents, significantly broadening their application spectrum.

Freeze-dried Collagen Sponge:

Freeze-dried collagen sponges represent a specialized segment within the market that offers enhanced stability and shelf life. The freeze-drying process concentrates the collagen and removes moisture, which not only preserves the structural integrity of the sponge but also facilitates easy storage and transport. These sponges are utilized primarily in surgical applications where precise delivery of collagen is critical. Their unique properties make them suitable for managing complex wounds and promoting faster healing times. The demand for freeze-dried collagen sponges is expected to rise as healthcare providers seek reliable and efficient solutions for wound management.

Others:

In addition to the aforementioned types, there are other collagen sponge variations that cater to specific medical needs. These may include modified or hybrid collagen sponges that incorporate various materials for enhanced performance. Innovations in this category continue to emerge, driven by the need for more effective biomaterials that can cater to diverse clinical applications. As research progresses, these alternative types are expected to gain market share, driven by advancements in material science and a better understanding of their applications across different medical disciplines.

By Application

Orthopedic Surgeries:

Orthopedic surgeries represent a substantial application area for collagen sponges, where they are used to support bone repair and regeneration. In procedures such as joint reconstruction, spinal surgery, and fracture repairs, collagen sponges provide a scaffold that enhances cellular activity and tissue integration. Their excellent mechanical properties and biocompatibility make them an ideal choice for orthopedic applications. As the incidence of orthopedic conditions continues to rise, the demand for collagen sponges in this sector is expected to grow significantly, driven by advancements in surgical techniques and increased patient awareness regarding treatment options.

Dental Surgeries:

In dental surgeries, collagen sponges are crucial in promoting healing and tissue regeneration following procedures such as dental implants and periodontal surgeries. Their ability to support blood clot formation and soft tissue regeneration is essential for successful outcomes in these scenarios. Collagen sponges facilitate the healing process and minimize complications associated with dental surgeries. As dental aesthetics and restorative procedures become more prevalent, the demand for collagen-based products in the dental sector is likely to rise significantly, further propelling market growth.

Wound Care:

The wound care segment is one of the largest contributors to the collagen sponge market, as these sponges play a vital role in managing both acute and chronic wounds. Collagen sponges create an optimal healing environment by providing moisture while allowing for exudate absorption. Their properties promote faster healing and reduce the risk of infection, making them an essential tool in wound management. As the prevalence of chronic wounds, such as diabetic ulcers and pressure sores, continues to rise, the demand for effective wound care solutions, including collagen sponges, is on the increase. The focus on personalized wound care strategies will further enhance the growth of this segment.

Dermatology:

In dermatology, collagen sponges are increasingly being utilized for skin grafting procedures and wound healing applications, especially for burns and traumatic injuries. Their natural composition and ability to integrate well with skin tissues make them advantageous for reconstructive surgeries. Collagen sponges not only facilitate healing but also help restore the natural appearance of the skin post-surgery. The growing emphasis on skin health and aesthetic improvements is likely to drive demand in this application area, as more practitioners adopt collagen-based solutions in dermatological practices.

Others:

Other applications for collagen sponges include their utilization in cosmetic procedures, regenerative medicine, and veterinary applications. In cosmetic surgery, they can be deployed for skin rejuvenation, while in regenerative medicine, they serve as scaffolding for cell and tissue therapy. Their versatile nature and adaptability to various medical applications will ensure that the “Others” segment continues to grow, driven by innovations and expanding research into new potential uses for collagen sponges across diverse fields.

By Distribution Channel

Hospitals & Clinics:

The hospitals and clinics distribution channel is a major segment for the collagen sponge market, as these facilities are primary providers of surgical and wound care products. Collagen sponges are commonly used in operating rooms and post-operative care settings, making hospitals essential stakeholders in the market. The demand for collagen sponges in these environments is bolstered by the increasing number of surgical procedures and the focus on improving patient outcomes. Furthermore, hospitals often collaborate with manufacturers to ensure a steady supply of quality products, enhancing the availability and adoption of collagen sponges in clinical settings.

Retail Pharmacies:

Retail pharmacies play a vital role in the distribution of collagen sponges, specifically those designed for wound care management. Patients often seek out these products for home care, making pharmacies a convenient access point. The increasing awareness among consumers about the benefits of collagen sponges in healing is driving growth in this channel. Retail pharmacies are adapting their offerings to accommodate this demand by stocking various types of collagen sponges and providing guidance on their usage, thus enhancing market penetration.

E-commerce:

The e-commerce distribution channel is rapidly gaining traction in the collagen sponge market, driven by the increasing popularity of online shopping. Consumers appreciate the convenience of purchasing medical supplies from the comfort of their homes, along with access to a wider range of products and competitive pricing. E-commerce platforms allow for direct sales from manufacturers, reducing costs and ensuring a steady supply of collagen sponges. The growth of this channel is also supported by the rise of telemedicine and digital health initiatives, which encourage patients to seek out products online, further enhancing the collagen sponge market's reach.

Drug Stores:

Drug stores represent another important distribution channel for collagen sponges, catering to consumers seeking over-the-counter wound care solutions. These establishments provide easy access to collagen products, especially for individuals managing chronic wounds or those recovering from minor surgical procedures. The convenience factor and the trusted relationship consumers have with drug stores make them a popular choice for purchasing medical supplies. As awareness of the benefits of collagen sponges continues to grow, drug stores are expected to expand their offerings, thereby driving market growth.

Others:

In addition to the aforementioned distribution channels, other avenues such as specialty medical supply stores and direct sales from manufacturers contribute to the market for collagen sponges. Specialty stores often focus on niche markets, providing tailored solutions for specific medical needs, whereas manufacturers may establish direct relationships with healthcare providers for bulk purchases. The combination of various distribution channels ensures that collagen sponges are widely accessible, addressing the needs of different consumer segments and enhancing overall market growth.

By Ingredient Type

Type I Collagen:

Type I collagen is the most abundant form of collagen in the human body and is widely utilized in collagen sponge products due to its excellent biocompatibility and mechanical properties. These sponges are particularly effective in wound healing applications, as they promote cell migration, proliferation, and differentiation, leading to enhanced tissue repair. They are commonly employed in surgical settings and chronic wound care management, making them a significant segment within the market. With the ongoing research into improving wound healing outcomes, Type I collagen sponges are expected to maintain a strong market presence.

Type II Collagen:

Type II collagen is primarily found in cartilage and is increasingly being utilized in orthopedic applications. Collagen sponges made from Type II collagen are specifically designed to support cartilage regeneration and repair in joint-related surgeries. Their unique properties make them suitable for use in conditions such as osteoarthritis and other degenerative joint diseases. As the demand for effective solutions in orthopedic surgery continues to escalate, the market for Type II collagen sponges is anticipated to grow in tandem, driven by advancements in surgical techniques and orthopedic care.

Type III Collagen:

Type III collagen is often associated with skin and blood vessel structure, making it particularly valuable in cosmetic and dermatological applications. Collagen sponges containing Type III collagen are utilized in skin grafting and reconstructive surgeries, where they aid in promoting healing and minimizing scarring. As the trend toward aesthetic procedures rises among consumers, the demand for Type III collagen sponges is likely to increase significantly, positioning them as a key player in the market.

Type V Collagen:

Type V collagen plays a supportive role in the formation of collagen fibrils and is vital for the proper assembly of tissues. Its inclusion in collagen sponges can enhance the structural integrity and functionality of the product. Although less well-known than Type I and Type III collagens, Type V collagen is finding its place in specialized applications, particularly in regenerative medicine and advanced wound care. As research continues to elucidate its benefits, Type V collagen sponges may gain traction, expanding their market share.

Others:

This category encompasses other types of collagen and innovative formulations that combine various collagen types or integrate synthetic alternatives. Research into the properties of lesser-known collagen types is ongoing, and these sponges may cater to niche markets or specific clinical needs. The exploration of new formulations reflects the evolving landscape of the collagen sponge market, as manufacturers seek to create versatile products that meet diverse medical requirements and enhance healing.

By Region

The North America region is currently the largest market for collagen sponges, holding approximately 40% of the total market share in 2023. The growth in this region is attributed to advanced healthcare systems, high disposable income, and a strong emphasis on innovative medical technologies. The increasing incidence of surgical procedures and chronic wounds, combined with heightened consumer awareness regarding effective wound care products, is driving robust demand for collagen sponges. Additionally, the presence of major players and ongoing research initiatives further solidify North America's leading position in the market.

Europe follows closely, accounting for roughly 30% of the global collagen sponge market, with a CAGR of 6.2% projected over the forecast period. The region benefits from a strong healthcare infrastructure, with an increasing focus on wound care management and surgical innovations. The aging population and the rising prevalence of chronic conditions are contributing to the growing demand for collagen-based products across European countries. Furthermore, regulatory support for advanced wound care products is fostering a conducive environment for market expansion, enabling further advancements and increased accessibility to collagen sponges throughout the region.

Opportunities

The collagen sponge market is poised for significant opportunities, particularly with the increasing focus on regenerative medicine and tissue engineering. As research continues to uncover the potential of collagen-based products in promoting healing and tissue repair, manufacturers can capitalize on this trend by developing innovative solutions that cater to specific medical applications. Collaborations between research institutions and industry players can lead to the introduction of advanced collagen sponges with enhanced biocompatibility and functionality. Furthermore, as healthcare providers increasingly adopt minimally invasive surgical techniques, the demand for collagen sponges tailored for such procedures is expected to rise, presenting lucrative opportunities for market players. The growing interest in personalized medicine also opens avenues for the development of customized collagen-based solutions, enabling better patient outcomes and satisfaction.

Another promising opportunity lies in the expansion of the collagen sponge market in developing regions. As healthcare infrastructure improves and access to medical supplies increases, the demand for advanced wound care products is expected to surge. Companies can explore these emerging markets by partnering with local distributors and healthcare providers to ensure their collagen sponge offerings reach a wider audience. Additionally, increasing public awareness regarding chronic wounds and their management will likely drive demand for collagen sponges, bolstering market growth. The potential for online sales and e-commerce platforms presents another viable route for expanding market presence, particularly among consumers seeking convenient access to medical supplies.

Threats

Despite the promising outlook for the collagen sponge market, certain threats could hinder its growth trajectory. One significant challenge is the presence of alternative wound care technologies and products, which may offer competitive advantages in terms of cost, effectiveness, or ease of application. As new innovations emerge in the wound care landscape, manufacturers of collagen sponges must remain vigilant and responsive to market trends, adapting their product offerings to meet changing consumer preferences. Additionally, the regulatory landscape can pose challenges, as companies must navigate stringent approval processes and compliance requirements that may delay product launches or increase operational costs. The potential for supply chain disruptions, particularly with raw material sourcing, could also impact the availability and pricing of collagen sponges, presenting further challenges for market players.

Another significant restraining factor is the limited awareness of collagen sponge products among healthcare providers and patients, particularly in emerging markets. While the benefits of collagen sponges are well-documented, there remains a need for education and outreach efforts to inform stakeholders about their advantages and applicability in various medical scenarios. Without proper awareness, the adoption of collagen sponges may be hindered, affecting overall market growth. Additionally, the price sensitivity of certain consumer segments may restrict market expansion, particularly in regions where alternative products are more affordable. Addressing these threats will be crucial for companies aiming to sustain their competitive edge in the evolving collagen sponge market.

Competitor Outlook

• Integra LifeSciences Corporation
• Collagen Solutions Plc
• Smith & Nephew plc
• Medtronic PLC
• Zimmer Biomet Holdings, Inc.
• Allergan, Inc.
• Johnson & Johnson
• Osiris Therapeutics, Inc.
• Royal DSM
• Hollister Incorporated
• Stryker Corporation
• Advanced Biologics LLC
• Ethicon, Inc.
• Regenicin, Inc.
• W. L. Gore & Associates, Inc.

The competitive landscape of the collagen sponge market is characterized by the presence of various established players and emerging companies that are continually innovating and expanding their offerings. The market features a mix of global corporations and specialized firms, each vying for market share through strategic collaborations, product launches, and investments in research and development. These companies are focused on enhancing their product lines to meet the diverse needs of healthcare providers and patients, which is critical in a competitive environment where technology and consumer preferences are rapidly evolving. The emphasis on developing advanced wound care solutions and regenerative products is a common theme among market participants, reflecting the industry's focus on improving patient outcomes.

Integra LifeSciences Corporation is a leading player in the collagen sponge segment, leveraging its extensive experience in regenerative medicine and advanced wound care. The company's innovative products, such as their dermal regeneration templates, have solidified their position in the market. Collagen Solutions Plc is another key competitor, specializing in collagen-based biomaterials for various applications, including wound care and reconstructive surgery. Their commitment to quality and sustainability has garnered a loyal customer base, further enhancing their market presence. Smith & Nephew plc, known for its advanced wound management solutions, is also actively involved in the development of collagen sponges, emphasizing innovation and quality in their product offerings.

Medtronic PLC, a global leader in medical technology, has expanded its portfolio to include collagen-based products, focusing on advanced surgical applications and wound care management. Their extensive research and development efforts have resulted in a range of effective solutions that cater to diverse medical needs. Zimmer Biomet Holdings, Inc. specializes in orthopedic solutions and has incorporated collagen sponges into its offerings, particularly for cartilage repair and regeneration. The company's focus on innovation and improving surgical outcomes has positioned them favorably in the market. Lastly, Johnson & Johnson, with its well-established reputation in the healthcare sector, has been actively investing in collagen sponge technology, enhancing its product portfolio to meet the growing demand for effective wound care solutions.

• 1 Appendix

  • 1.1 List of Tables
  • 1.2 List of Figures

• 2 Introduction

  • 2.1 Market Definition
  • 2.2 Scope of the Report
  • 2.3 Study Assumptions
  • 2.4 Base Currency & Forecast Periods

• 3 Market Dynamics

  • 3.1 Market Growth Factors
  • 3.2 Economic & Global Events
  • 3.3 Innovation Trends
  • 3.4 Supply Chain Analysis

• 4 Consumer Behavior

  • 4.1 Market Trends
  • 4.2 Pricing Analysis
  • 4.3 Buyer Insights

• 5 Key Player Profiles

  • 5.1 Royal DSM
    • 5.1.1 Business Overview
    • 5.1.2 Products & Services
    • 5.1.3 Financials
    • 5.1.4 Recent Developments
    • 5.1.5 SWOT Analysis
  • 5.2 Ethicon, Inc.
    • 5.2.1 Business Overview
    • 5.2.2 Products & Services
    • 5.2.3 Financials
    • 5.2.4 Recent Developments
    • 5.2.5 SWOT Analysis
  • 5.3 Medtronic PLC
    • 5.3.1 Business Overview
    • 5.3.2 Products & Services
    • 5.3.3 Financials
    • 5.3.4 Recent Developments
    • 5.3.5 SWOT Analysis
  • 5.4 Allergan, Inc.
    • 5.4.1 Business Overview
    • 5.4.2 Products & Services
    • 5.4.3 Financials
    • 5.4.4 Recent Developments
    • 5.4.5 SWOT Analysis
  • 5.5 Regenicin, Inc.
    • 5.5.1 Business Overview
    • 5.5.2 Products & Services
    • 5.5.3 Financials
    • 5.5.4 Recent Developments
    • 5.5.5 SWOT Analysis
  • 5.6 Johnson & Johnson
    • 5.6.1 Business Overview
    • 5.6.2 Products & Services
    • 5.6.3 Financials
    • 5.6.4 Recent Developments
    • 5.6.5 SWOT Analysis
  • 5.7 Smith & Nephew plc
    • 5.7.1 Business Overview
    • 5.7.2 Products & Services
    • 5.7.3 Financials
    • 5.7.4 Recent Developments
    • 5.7.5 SWOT Analysis
  • 5.8 Stryker Corporation
    • 5.8.1 Business Overview
    • 5.8.2 Products & Services
    • 5.8.3 Financials
    • 5.8.4 Recent Developments
    • 5.8.5 SWOT Analysis
  • 5.9 Advanced Biologics LLC
    • 5.9.1 Business Overview
    • 5.9.2 Products & Services
    • 5.9.3 Financials
    • 5.9.4 Recent Developments
    • 5.9.5 SWOT Analysis
  • 5.10 Collagen Solutions Plc
    • 5.10.1 Business Overview
    • 5.10.2 Products & Services
    • 5.10.3 Financials
    • 5.10.4 Recent Developments
    • 5.10.5 SWOT Analysis
  • 5.11 Hollister Incorporated
    • 5.11.1 Business Overview
    • 5.11.2 Products & Services
    • 5.11.3 Financials
    • 5.11.4 Recent Developments
    • 5.11.5 SWOT Analysis
  • 5.12 Osiris Therapeutics, Inc.
    • 5.12.1 Business Overview
    • 5.12.2 Products & Services
    • 5.12.3 Financials
    • 5.12.4 Recent Developments
    • 5.12.5 SWOT Analysis
  • 5.13 Zimmer Biomet Holdings, Inc.
    • 5.13.1 Business Overview
    • 5.13.2 Products & Services
    • 5.13.3 Financials
    • 5.13.4 Recent Developments
    • 5.13.5 SWOT Analysis
  • 5.14 W. L. Gore & Associates, Inc.
    • 5.14.1 Business Overview
    • 5.14.2 Products & Services
    • 5.14.3 Financials
    • 5.14.4 Recent Developments
    • 5.14.5 SWOT Analysis
  • 5.15 Integra LifeSciences Corporation
    • 5.15.1 Business Overview
    • 5.15.2 Products & Services
    • 5.15.3 Financials
    • 5.15.4 Recent Developments
    • 5.15.5 SWOT Analysis

• 6 Market Segmentation

  • 6.1 Collagen Sponge Market, By Application
    • 6.1.1 Orthopedic Surgeries
    • 6.1.2 Dental Surgeries
    • 6.1.3 Wound Care
    • 6.1.4 Dermatology
    • 6.1.5 Others
  • 6.2 Collagen Sponge Market, By Product Type
    • 6.2.1 Gelatin-based Collagen Sponge
    • 6.2.2 Native Collagen Sponge
    • 6.2.3 Composite Collagen Sponge
    • 6.2.4 Freeze-dried Collagen Sponge
    • 6.2.5 Others
  • 6.3 Collagen Sponge Market, By Ingredient Type
    • 6.3.1 Type I Collagen
    • 6.3.2 Type II Collagen
    • 6.3.3 Type III Collagen
    • 6.3.4 Type V Collagen
    • 6.3.5 Others
  • 6.4 Collagen Sponge Market, By Distribution Channel
    • 6.4.1 Hospitals & Clinics
    • 6.4.2 Retail Pharmacies
    • 6.4.3 E-commerce
    • 6.4.4 Drug Stores
    • 6.4.5 Others

• 7 Competitive Analysis

  • 7.1 Key Player Comparison
  • 7.2 Market Share Analysis
  • 7.3 Investment Trends
  • 7.4 SWOT Analysis

• 8 Research Methodology

  • 8.1 Analysis Design
  • 8.2 Research Phases
  • 8.3 Study Timeline

• 9 Future Market Outlook

  • 9.1 Growth Forecast
  • 9.2 Market Evolution

• 10 Geographical Overview

  • 10.1 Europe - Market Analysis
    • 10.1.1 By Country
      • 10.1.1.1 UK
      • 10.1.1.2 France
      • 10.1.1.3 Germany
      • 10.1.1.4 Spain
      • 10.1.1.5 Italy
  • 10.2 Asia Pacific - Market Analysis
    • 10.2.1 By Country
      • 10.2.1.1 India
      • 10.2.1.2 China
      • 10.2.1.3 Japan
      • 10.2.1.4 South Korea
  • 10.3 Latin America - Market Analysis
    • 10.3.1 By Country
      • 10.3.1.1 Brazil
      • 10.3.1.2 Argentina
      • 10.3.1.3 Mexico
  • 10.4 North America - Market Analysis
    • 10.4.1 By Country
      • 10.4.1.1 USA
      • 10.4.1.2 Canada
  • 10.5 Collagen Sponge Market by Region
  • 10.6 Middle East & Africa - Market Analysis
    • 10.6.1 By Country
      • 10.6.1.1 Middle East
      • 10.6.1.2 Africa

• 11 Global Economic Factors

  • 11.1 Inflation Impact
  • 11.2 Trade Policies

• 12 Technology & Innovation

  • 12.1 Emerging Technologies
  • 12.2 AI & Digital Trends
  • 12.3 Patent Research

• 13 Investment & Market Growth

  • 13.1 Funding Trends
  • 13.2 Future Market Projections

• 14 Market Overview & Key Insights

  • 14.1 Executive Summary
  • 14.2 Key Trends
  • 14.3 Market Challenges
  • 14.4 Regulatory Landscape

Segments Analyzed in the Report

The global Collagen Sponge market is categorized based on

By Product Type

• Gelatin-based Collagen Sponge
• Native Collagen Sponge
• Composite Collagen Sponge
• Freeze-dried Collagen Sponge
• Others

By Application

• Orthopedic Surgeries
• Dental Surgeries
• Wound Care
• Dermatology
• Others

By Distribution Channel

• Hospitals & Clinics
• Retail Pharmacies
• E-commerce
• Drug Stores
• Others

By Ingredient Type

• Type I Collagen
• Type II Collagen
• Type III Collagen
• Type V Collagen
• Others

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

Key Players

• Integra LifeSciences Corporation
• Collagen Solutions Plc
• Smith & Nephew plc
• Medtronic PLC
• Zimmer Biomet Holdings, Inc.
• Allergan, Inc.
• Johnson & Johnson
• Osiris Therapeutics, Inc.
• Royal DSM
• Hollister Incorporated
• Stryker Corporation
• Advanced Biologics LLC
• Ethicon, Inc.
• Regenicin, Inc.
• W. L. Gore & Associates, Inc.