Annuloplasty Ring Sales

Annuloplasty Ring Sales Market Outlook

The global annuloplasty ring market is projected to reach USD 3.5 billion by 2035, with a significant compound annual growth rate (CAGR) of 8.3% during the forecast period from 2025 to 2035. This growth is primarily driven by the increasing prevalence of heart valve diseases and the rising number of cardiovascular surgeries performed worldwide. Furthermore, advancements in surgical techniques and technologies related to annuloplasty rings are enhancing the efficacy and safety of heart surgeries, resulting in a growing acceptance and demand for annuloplasty rings. The aging population, particularly in developed countries, is expected to further push the market as age-related health issues become more prevalent. Increased investments in healthcare infrastructure and research and development for innovative annuloplasty products are also vital factors contributing to this market's growth.

Growth Factor of the Market

The annuloplasty ring market is experiencing robust growth due to several key factors. First, the rising incidence of heart diseases, particularly valve disorders, necessitates effective surgical interventions, leading to an increased demand for annuloplasty rings. As healthcare systems evolve, there's a growing emphasis on minimally invasive procedures which further drives the market, as annuloplasty rings are integral to such surgeries. The technological advancements in the design and material of annuloplasty rings, such as the development of bioengineered products, are also enhancing patient outcomes and making these devices more appealing to surgeons. Additionally, the increasing awareness of preventive healthcare measures and the importance of regular cardiovascular check-ups are influencing patients and healthcare providers to opt for surgical solutions when necessary. The integration of robotics and artificial intelligence in cardiac surgeries could also offer potential growth avenues for the annuloplasty ring market.

Key Highlights of the Market

• Projected market size to reach USD 3.5 billion by 2035.
• Strong CAGR of 8.3% from 2025 to 2035.
• Rising incidence of heart valve diseases driving demand.
• Technological advancements in surgical techniques enhancing effectiveness.
• Increasing preference for minimally invasive surgical procedures.

By Product Type

Mechanical Annuloplasty Rings:

Mechanical annuloplasty rings are designed for durability and stability, making them a popular choice among surgeons for various cardiac repair procedures. These rings are made from materials that provide excellent structural support, which is necessary for patients undergoing valve repair surgeries. The longevity and resistance to deformation of mechanical rings are significant advantages, especially in younger patients who are likely to live longer post-surgery. Their usage is frequently accompanied by a robust monitoring regimen to manage potential complications, such as thrombosis. Owing to these factors, the mechanical annuloplasty ring segment is anticipated to hold a substantial share of the market throughout the forecast period.

Bioprosthetic Annuloplasty Rings:

Bioprosthetic annuloplasty rings are increasingly favored due to their compatibility with human tissue, significantly reducing the risk of rejection. These rings are typically made from animal tissue or a combination of biological materials and synthetic elements. They provide a more natural feel and are less prone to calcification compared to mechanical options, making them suitable for many patients, including the elderly. Bioprosthetic rings are also associated with lower rates of anticoagulation therapy post-surgery, enhancing patient compliance and comfort. This segment is expected to grow steadily as more clinicians recognize the benefits of biological materials in cardiac repairs.

Annuloplasty Bands:

Annuloplasty bands are a more flexible alternative used in a variety of heart procedures, including those involving valve repairs. They offer unique advantages, such as easier manipulation during surgery and the ability to adjust to varying anatomical shapes of the heart. The application of annuloplasty bands is particularly significant in pediatric surgeries, where adaptability is crucial. This segment is projected to see substantial growth as surgical techniques evolve and more surgeons adopt bands for their procedural versatility. The increasing acceptance and application of annuloplasty bands in various surgical environments underscore their importance within the annuloplasty ring market.

Flexible Annuloplasty Rings:

Flexible annuloplasty rings have gained traction due to their ability to conform to the natural motion of the heart, providing a more dynamic solution for valve repair procedures. These rings are ideal for patients requiring a more adaptable support system, as they can accommodate the physiological changes that occur post-surgery. The flexibility enhances the overall biomechanical performance of the valve, promoting a more natural blood flow. As the healthcare industry continues to emphasize patient-centered approaches, the segment of flexible annuloplasty rings is likely to see increased adoption as surgeons recognize their advantages.

Semi-Rigid Annuloplasty Rings:

Semi-rigid annuloplasty rings offer a balance between support and flexibility, making them suitable for a range of surgical applications. These rings are designed to maintain structural integrity while still allowing for some degree of movement, accommodating the heart’s natural dynamics. Surgeons appreciate the versatility of semi-rigid rings, as they can be used effectively in various patient demographics, including those with more complex cardiac conditions. The growing trend toward personalized medicine is likely to bolster the semi-rigid annuloplasty ring market, as these devices can be tailored to individual patient needs, ensuring better surgical outcomes.

By Application

Mitral Valve Repair:

Mitral valve repair is one of the most common applications for annuloplasty rings, driven by the rising prevalence of mitral valve insufficiency. Surgical techniques for repairing the mitral valve have evolved, and annuloplasty rings play a crucial role in ensuring the valve's proper function post-operation. The integration of annuloplasty rings leads to improved outcomes, reduced hospital stays, and decreased rates of reoperation. As healthcare providers continue to prioritize effective solutions for mitral valve diseases, this segment is projected to dominate the annuloplasty ring market significantly, ensuring steady growth over the forecast period.

Tricuspid Valve Repair:

Tricuspid valve repair is becoming increasingly important in cardiac surgery, especially as awareness grows regarding the consequences of untreated tricuspid regurgitation. Annuloplasty rings are essential tools in tricuspid valve reconstruction, helping to restore proper valve function and improve patient prognosis. The market for annuloplasty rings used specifically for tricuspid repairs is expected to grow as more patients are diagnosed and treated for related conditions. With the rising emphasis on comprehensive cardiac care, the tricuspid valve repair application will likely gain significant traction in the annuloplasty ring market.

Aortic Valve Repair:

Aortic valve repair is a critical application of annuloplasty rings, particularly due to the increasing incidence of aortic stenosis and regurgitation among the aging population. Effective surgical intervention using annuloplasty rings can substantially improve patient outcomes, making it an essential area of focus in cardiac procedures. The need for aortic valve repair is expected to grow, driven by demographic trends and advancements in surgical techniques. This segment is poised for significant expansion as more healthcare facilities adopt modern approaches to aortic valve problems, fostering the growth of annuloplasty ring use.

Pulmonary Valve Repair:

Pulmonary valve repair, while less common than other applications, represents a niche but growing segment where annuloplasty rings are utilized. Annuloplasty rings aid in the repair of pulmonary valve insufficiency, enhancing the valve's functionality. The focus on pediatric and congenital heart conditions has brought renewed attention to this application, as effective pulmonary valve repair can profoundly impact a patient’s quality of life. Given the advancements in surgical methodologies and increased awareness of congenital heart disease, the pulmonary valve repair segment is anticipated to grow steadily, contributing positively to the overall annuloplasty ring market.

Others:

The "Others" segment includes various applications where annuloplasty rings may be utilized, such as in experimental or less common valve repairs. Innovations in cardiac surgery continuously create new applications for annuloplasty rings, with ongoing research and clinical trials looking to expand their usage. The versatility of annuloplasty rings means that their application is likely to increase across various subfields within cardiac surgery, contributing to a steady market growth. As surgical techniques advance and new indications are discovered, this segment could see significant developments in the coming years.

By Distribution Channel

Hospitals:

Hospitals remain the primary distribution channel for annuloplasty rings, accounting for a significant share of the market due to their extensive surgical facilities and specialized cardiac care units. In-hospital procedures provide access to a broad range of surgical resources, including experienced cardiac surgeons and comprehensive post-operative care. Owing to the high volume of surgical cases, hospitals are integral to the annuloplasty ring market, facilitating rapid adoption of new technologies and treatments. As hospitals continue to enhance their cardiac service offerings and infrastructure, this distribution channel is expected to witness consistent growth over the forecast period.

Ambulatory Surgical Centers:

Ambulatory surgical centers (ASCs) are gaining traction as a viable distribution channel for annuloplasty rings, primarily due to the increasing trend toward outpatient surgical procedures. These centers provide a cost-effective alternative to traditional hospitals, often resulting in lower overall healthcare expenses. The rise in outpatient surgeries, enhanced by advancements in surgical techniques and patient recovery protocols, supports the growth of annuloplasty rings in ASCs. This segment is expected to expand as patients and healthcare providers recognize the benefits of outpatient facilities, including expedited recovery times and reduced hospital stays.

Cardiac Clinics:

Cardiac clinics are specialized facilities focusing on cardiovascular health, making them important distribution channels for annuloplasty rings. These clinics provide dedicated services for diagnosing and treating heart conditions, allowing for timely interventions and surgical procedures. The growth of cardiac clinics is driven by an increasing emphasis on preventive care and patient education regarding heart health. As more patients seek specialized care for heart valve issues, the role of cardiac clinics in the annuloplasty ring market is likely to expand, thereby contributing to overall market growth.

Online Sales:

Online sales channels for annuloplasty rings are an emerging segment, reflecting the ongoing digital transformation within the healthcare industry. E-commerce platforms allow for convenience and accessibility, enabling healthcare providers to source surgical products quickly and efficiently. The ability to compare products and prices online adds a layer of transparency to the procurement process. As healthcare facilities increasingly embrace technology and digital solutions, the online sales distribution channel is expected to grow, particularly among smaller clinics and surgical centers seeking cost-effective options for annuloplasty devices.

By Material Type

Titanium:

Titanium is a popular material choice for annuloplasty rings due to its excellent biocompatibility and strength-to-weight ratio. Its resistance to corrosion and fatigue makes it a durable option for long-term use within the human body. The use of titanium in annuloplasty rings aligns with the increasing focus on patient safety and the need for devices that minimize complications. As more clinicians recognize the benefits of titanium-based devices, this segment is anticipated to gain a larger market share, with a continuous influx of innovative designs utilizing this advanced material.

Stainless Steel:

Stainless steel is another widely used material in the manufacturing of annuloplasty rings, primarily due to its mechanical properties and affordability. The strength and reliability of stainless steel make it suitable for high-pressure environments within the heart. Additionally, advancements in surface treatments for stainless steel can enhance its biocompatibility, furthering its application in cardiac surgery. As the focus on cost-effective yet robust solutions increases, the stainless steel material type is expected to maintain a significant presence in the annuloplasty ring market.

Carbon Based:

Carbon-based materials are gaining attention in the annuloplasty ring segment for their unique properties, including biocompatibility and resistance to thrombosis. Innovations in carbon-based composites are enabling the development of annuloplasty rings that offer enhanced performance and reduced risk of complications post-surgery. The growing research and development efforts surrounding carbon-based materials are expected to propel this segment forward, as they align with the trends towards more advanced and safer surgical devices. The adoption of carbon-based annuloplasty rings may witness robust growth as more data becomes available regarding their efficacy and safety.

Silicone:

Silicone is known for its flexibility and biocompatibility, making it a favorable option for certain types of annuloplasty rings. The softness and adaptability of silicone enable better integration with surrounding tissues, which can enhance the healing process post-surgery. This material is particularly useful in pediatric applications, where growth and adaptability are critical considerations. As the market for silicone-based annuloplasty rings expands, particularly in niche applications, this material type is expected to carve out a substantial share of the overall annuloplasty ring market.

Others:

The "Others" segment encompasses various alternative materials utilized in the production of annuloplasty rings, including innovative synthetic and hybrid materials. Ongoing research into new polymers and composites is expanding the range of available annuloplasty products, aiming to improve functionality and patient outcomes. As healthcare professionals increasingly seek tailored solutions for their patients, the demand for alternative materials is likely to grow, driving innovation within this segment. The exploration of new materials could lead to the introduction of groundbreaking annuloplasty devices, enhancing the overall market landscape.

By Region

North America holds a dominant position in the annuloplasty ring market, accounting for approximately 40% of the global market share in 2025. The region's extensive healthcare infrastructure, coupled with a high prevalence of cardiovascular diseases, contributes significantly to this market leadership. Additionally, the presence of key players and ongoing advancements in medical technology further bolster the market in North America. The CAGR for this region is projected to be around 8.5% during the forecast period, driven by innovations and the increasing adoption of minimally invasive surgical techniques.

In Europe, the annuloplasty ring market is expected to experience steady growth, with a significant contribution from countries like Germany, France, and the United Kingdom. The regional market is projected to reach USD 1.1 billion by 2035, fueled by a strong emphasis on cardiac care and an aging population susceptible to heart diseases. The European market is expected to grow at a CAGR of 7.8% during the forecast period, driven by the rising number of hospital admissions for cardiovascular procedures and the expanding availability of advanced annuloplasty devices.

Opportunities

The annuloplasty ring market presents substantial opportunities for growth, particularly in emerging economies where healthcare systems are evolving and investments in cardiac care are increasing. Countries in Asia Pacific and Latin America are witnessing rapid improvements in healthcare infrastructure, leading to better access to advanced surgical techniques and devices. The rising middle-class population in these regions is also driving demand for high-quality medical care, including cardiac surgeries. This trend creates a significant opportunity for manufacturers and suppliers of annuloplasty rings to introduce their products into new markets, potentially resulting in lucrative partnerships and collaborations with local healthcare institutions.

Furthermore, the continued emphasis on medical research and innovation offers a plethora of opportunities for manufacturers to develop next-generation annuloplasty rings. The integration of smart technologies, such as sensors that can monitor the condition of the heart post-surgery, presents an exciting frontier for product development. As healthcare providers strive to enhance patient outcomes and reduce the risks associated with cardiac surgeries, investing in R&D to create more effective and safer annuloplasty solutions will be paramount. Companies that successfully harness these technological advancements stand to gain a competitive edge and carve out a strong presence in the global annuloplasty ring market.

Threats

While the annuloplasty ring market is poised for growth, several threats could impact its trajectory. One significant concern is the potential for adverse events or complications arising from the use of annuloplasty rings in surgical procedures. Complications such as infection, thrombosis, or device failure could lead to negative outcomes, potentially damaging the reputation of specific products and manufacturers. Additionally, the medical device industry is heavily regulated, with stringent requirements for approval and market entry, which can create barriers for new entrants. Companies may face challenges in navigating the complex regulatory landscape, particularly in light of increasingly rigorous safety and efficacy standards.

Moreover, fierce competition among existing players could suppress profit margins and hinder innovation. The presence of established brands with strong market positions can make it difficult for newcomers to penetrate the market. Strategic pricing pressures and the need to continuously innovate can strain resources for smaller companies, limiting their ability to compete effectively. As the annuloplasty ring market matures, the threat of consolidation among major players may further intensify competitive pressures, leading to a challenging environment for new entrants and smaller companies seeking to establish a foothold.

Competitor Outlook

• Edwards Lifesciences Corporation
• Medtronic plc
• Abbott Laboratories
• Sorin Group
• Boston Scientific Corporation
• JenaValve Technology, Inc.
• Cook Medical, Inc.
• Cardinal Health, Inc.
• Terumo Corporation
• LivaNova PLC
• Cardiovalve Ltd.
• Micro Interventional Devices, Inc.
• St. Jude Medical, Inc.
• LifeTech Scientific Corporation
• Neovasc Inc.

The competitive landscape of the annuloplasty ring market is characterized by the presence of several key players, each vying for market share through innovation, strategic partnerships, and mergers and acquisitions. Established companies like Edwards Lifesciences and Medtronic dominate the market, leveraging their extensive R&D capabilities and vast distribution networks to maintain their competitive edge. These companies are at the forefront of developing new technologies and improving existing products, ensuring they meet the evolving needs of healthcare providers and patients alike. Furthermore, they are investing heavily in clinical trials to validate the efficacy and safety of their annuloplasty devices, which is crucial for gaining regulatory approvals and building trust among surgeons.

In addition to major corporations, several emerging companies are making strides in the annuloplasty ring market by focusing on niche applications and innovative materials. Startups such as JenaValve Technology and Cardiovalve are developing unique solutions to address specific cardiovascular issues, positioning themselves as valuable players in the market. These companies are often more agile and can quickly adapt to changing market demands, allowing them to introduce novel products that cater to the specific needs of patients and healthcare providers. Collaborations between established firms and startups are becoming increasingly common, as they seek to combine resources and expertise to bring cutting-edge products to market more efficiently.

Key players in the annuloplasty ring market are also focusing on geographical expansion to tap into emerging markets, particularly in Asia Pacific and Latin America, where demand for advanced cardiac care is on the rise. Companies are establishing local partnerships and distribution networks to enhance their market presence and reach a broader customer base. Additionally, the growing trend toward personalized medicine and patient-centered care is encouraging manufacturers to develop customizable annuloplasty rings that cater to individual patient needs. This strategy not only addresses the diverse requirements of patients but also strengthens customer loyalty and enhances brand reputation in the competitive landscape.

• 1 Appendix

  • 1.1 List of Tables
  • 1.2 List of Figures

• 2 Introduction

  • 2.1 Market Definition
  • 2.2 Scope of the Report
  • 2.3 Study Assumptions
  • 2.4 Base Currency & Forecast Periods

• 3 Market Dynamics

  • 3.1 Market Growth Factors
  • 3.2 Economic & Global Events
  • 3.3 Innovation Trends
  • 3.4 Supply Chain Analysis

• 4 Consumer Behavior

  • 4.1 Market Trends
  • 4.2 Pricing Analysis
  • 4.3 Buyer Insights

• 5 Key Player Profiles

  • 5.1 Sorin Group
    • 5.1.1 Business Overview
    • 5.1.2 Products & Services
    • 5.1.3 Financials
    • 5.1.4 Recent Developments
    • 5.1.5 SWOT Analysis
  • 5.2 LivaNova PLC
    • 5.2.1 Business Overview
    • 5.2.2 Products & Services
    • 5.2.3 Financials
    • 5.2.4 Recent Developments
    • 5.2.5 SWOT Analysis
  • 5.3 Neovasc Inc.
    • 5.3.1 Business Overview
    • 5.3.2 Products & Services
    • 5.3.3 Financials
    • 5.3.4 Recent Developments
    • 5.3.5 SWOT Analysis
  • 5.4 Medtronic plc
    • 5.4.1 Business Overview
    • 5.4.2 Products & Services
    • 5.4.3 Financials
    • 5.4.4 Recent Developments
    • 5.4.5 SWOT Analysis
  • 5.5 Cardiovalve Ltd.
    • 5.5.1 Business Overview
    • 5.5.2 Products & Services
    • 5.5.3 Financials
    • 5.5.4 Recent Developments
    • 5.5.5 SWOT Analysis
  • 5.6 Cook Medical, Inc.
    • 5.6.1 Business Overview
    • 5.6.2 Products & Services
    • 5.6.3 Financials
    • 5.6.4 Recent Developments
    • 5.6.5 SWOT Analysis
  • 5.7 Terumo Corporation
    • 5.7.1 Business Overview
    • 5.7.2 Products & Services
    • 5.7.3 Financials
    • 5.7.4 Recent Developments
    • 5.7.5 SWOT Analysis
  • 5.8 Abbott Laboratories
    • 5.8.1 Business Overview
    • 5.8.2 Products & Services
    • 5.8.3 Financials
    • 5.8.4 Recent Developments
    • 5.8.5 SWOT Analysis
  • 5.9 Cardinal Health, Inc.
    • 5.9.1 Business Overview
    • 5.9.2 Products & Services
    • 5.9.3 Financials
    • 5.9.4 Recent Developments
    • 5.9.5 SWOT Analysis
  • 5.10 St. Jude Medical, Inc.
    • 5.10.1 Business Overview
    • 5.10.2 Products & Services
    • 5.10.3 Financials
    • 5.10.4 Recent Developments
    • 5.10.5 SWOT Analysis
  • 5.11 JenaValve Technology, Inc.
    • 5.11.1 Business Overview
    • 5.11.2 Products & Services
    • 5.11.3 Financials
    • 5.11.4 Recent Developments
    • 5.11.5 SWOT Analysis
  • 5.12 Boston Scientific Corporation
    • 5.12.1 Business Overview
    • 5.12.2 Products & Services
    • 5.12.3 Financials
    • 5.12.4 Recent Developments
    • 5.12.5 SWOT Analysis
  • 5.13 LifeTech Scientific Corporation
    • 5.13.1 Business Overview
    • 5.13.2 Products & Services
    • 5.13.3 Financials
    • 5.13.4 Recent Developments
    • 5.13.5 SWOT Analysis
  • 5.14 Edwards Lifesciences Corporation
    • 5.14.1 Business Overview
    • 5.14.2 Products & Services
    • 5.14.3 Financials
    • 5.14.4 Recent Developments
    • 5.14.5 SWOT Analysis
  • 5.15 Micro Interventional Devices, Inc.
    • 5.15.1 Business Overview
    • 5.15.2 Products & Services
    • 5.15.3 Financials
    • 5.15.4 Recent Developments
    • 5.15.5 SWOT Analysis

• 6 Market Segmentation

  • 6.1 Annuloplasty Ring Sales Market, By Application
    • 6.1.1 Mitral Valve Repair
    • 6.1.2 Tricuspid Valve Repair
    • 6.1.3 Aortic Valve Repair
    • 6.1.4 Pulmonary Valve Repair
    • 6.1.5 Others
  • 6.2 Annuloplasty Ring Sales Market, By Product Type
    • 6.2.1 Mechanical Annuloplasty Rings
    • 6.2.2 Bioprosthetic Annuloplasty Rings
    • 6.2.3 Annuloplasty Bands
    • 6.2.4 Flexible Annuloplasty Rings
    • 6.2.5 Semi-Rigid Annuloplasty Rings
  • 6.3 Annuloplasty Ring Sales Market, By Material Type
    • 6.3.1 Titanium
    • 6.3.2 Stainless Steel
    • 6.3.3 Carbon Based
    • 6.3.4 Silicone
    • 6.3.5 Others
  • 6.4 Annuloplasty Ring Sales Market, By Distribution Channel
    • 6.4.1 Hospitals
    • 6.4.2 Ambulatory Surgical Centers
    • 6.4.3 Cardiac Clinics
    • 6.4.4 Online Sales

• 7 Competitive Analysis

  • 7.1 Key Player Comparison
  • 7.2 Market Share Analysis
  • 7.3 Investment Trends
  • 7.4 SWOT Analysis

• 8 Research Methodology

  • 8.1 Analysis Design
  • 8.2 Research Phases
  • 8.3 Study Timeline

• 9 Future Market Outlook

  • 9.1 Growth Forecast
  • 9.2 Market Evolution

• 10 Geographical Overview

  • 10.1 Europe - Market Analysis
    • 10.1.1 By Country
      • 10.1.1.1 UK
      • 10.1.1.2 France
      • 10.1.1.3 Germany
      • 10.1.1.4 Spain
      • 10.1.1.5 Italy
  • 10.2 Asia Pacific - Market Analysis
    • 10.2.1 By Country
      • 10.2.1.1 India
      • 10.2.1.2 China
      • 10.2.1.3 Japan
      • 10.2.1.4 South Korea
  • 10.3 Latin America - Market Analysis
    • 10.3.1 By Country
      • 10.3.1.1 Brazil
      • 10.3.1.2 Argentina
      • 10.3.1.3 Mexico
  • 10.4 North America - Market Analysis
    • 10.4.1 By Country
      • 10.4.1.1 USA
      • 10.4.1.2 Canada
  • 10.5 Middle East & Africa - Market Analysis
    • 10.5.1 By Country
      • 10.5.1.1 Middle East
      • 10.5.1.2 Africa
  • 10.6 Annuloplasty Ring Sales Market by Region

• 11 Global Economic Factors

  • 11.1 Inflation Impact
  • 11.2 Trade Policies

• 12 Technology & Innovation

  • 12.1 Emerging Technologies
  • 12.2 AI & Digital Trends
  • 12.3 Patent Research

• 13 Investment & Market Growth

  • 13.1 Funding Trends
  • 13.2 Future Market Projections

• 14 Market Overview & Key Insights

  • 14.1 Executive Summary
  • 14.2 Key Trends
  • 14.3 Market Challenges
  • 14.4 Regulatory Landscape

Segments Analyzed in the Report

The global Annuloplasty Ring Sales market is categorized based on

By Product Type

• Mechanical Annuloplasty Rings
• Bioprosthetic Annuloplasty Rings
• Annuloplasty Bands
• Flexible Annuloplasty Rings
• Semi-Rigid Annuloplasty Rings

By Application

• Mitral Valve Repair
• Tricuspid Valve Repair
• Aortic Valve Repair
• Pulmonary Valve Repair
• Others

By Distribution Channel

• Hospitals
• Ambulatory Surgical Centers
• Cardiac Clinics
• Online Sales

By Material Type

• Titanium
• Stainless Steel
• Carbon Based
• Silicone
• Others

By Region

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

Key Players

• Edwards Lifesciences Corporation
• Medtronic plc
• Abbott Laboratories
• Sorin Group
• Boston Scientific Corporation
• JenaValve Technology, Inc.
• Cook Medical, Inc.
• Cardinal Health, Inc.
• Terumo Corporation
• LivaNova PLC
• Cardiovalve Ltd.
• Micro Interventional Devices, Inc.
• St. Jude Medical, Inc.
• LifeTech Scientific Corporation
• Neovasc Inc.